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Sulfobetaine 12

(Detergent zwitterionic)


S121   N-Dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate, 99+%
[ 14933-08-5 ]   f.w.: 335.6 daltons

A synthetic zwitterionic detergent, which unlike other amphoteric surfactants, retains its zwitterionic character over a broad pH range.



Quantity Price  
2gm $42.00
5gm $89.10
10gm $168.30


A synthetic zwitterionic detergent, which unlike other amphoteric surfactants, retains its zwitterionic character over a broad pH range. This property is attributed to the presence of both a strongly basic quaternary ammonium ion and an acidic sulfonate ion of equal strength. This ionic balance presumably prevents irreversible binding to either anionic or cationic compounds. Aggregation number: 55.

  1. Raper, S.E., et al. 1992. Hepatology 16, 433. 
  2. Nollstadt, K.H., et al. 1989. J. Chromatogr. 497, 87. 
  3. Byers, S., et al. 1987. J. Biol. Chem. 262, 9166.
  • CMC (20 mM Tris-HCl, pH 8.0, 0.1 M NaCl): ~ 2.8 mM (0.094%)
  • Aggregation Number (H2O)(2): ~ 55-87
  • Purity:  98% pure by HPLC analysis.
  • pH (1% solution): 5-8
  • Solubility in water at 20°C:  30%
  • Conductance (10% solution): < 70 micromhos
  • Percent fluorescence due to a 0.1% detergent solution at 345 nm: < 10
  • Absorbance of a 1% detergent solution: 340 nm: <0.02 280 nm: < 0.04 260 nm: < 0.06 225 nm: < 0.1