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GMBS

(Protein Crosslinker heterobifunctional)


CL231   N-(beta-Maleimidobutyrloxy)succinimide
[ 80307-12-6 ]   f.w.: 280.2 daltons

GMBS is an amine to sulfhydryl crosslinker that contains NHS ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).



Quantity Price  
50mgm $54.00
100mgm $102.00
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Spacer arm 6.8 angstroms. Heterobifunctional crosslinker. Analog of MBS, less immunogenic than SMCC. Non cleavable. Low potential for eliciting an immune response ensuring that their primary response to the antigen-carrier protein conjugate is not diluted by a response against a determinant on the crosslinker.

  1. Chrisey, L.A., et al. (1996). Nucleic Acids Res. 24(15), 3031-3039. 
  2. Fujiwara, K., et al. (1988). Sandwich enzyme immunoassay of tumor-associated antigen sialosylated Lewis (x) using beta-D-galactosidase coupled to a monoclonal antibody of IgM isotype. J. Immunol. Meth. 112, 77-83.

•GMBS has a low potential for eliciting an immune response, ensuring that the primary response is to the antigen-carrier protein conjugate and not against a determinant on the crosslinker •Less immunogenic than SMCC •Reactive groups: NHS ester and maleimide •Reactive toward: amino and sulfhydryl groups