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AEBSF hydrochloride

(Biochemical Reagent)


BR102   4-(2-Aminoethyl)benzene sulfonyl flouride hydrochloride, 99+%
[ 30827-99-7 ]   f.w.: 239.5daltons

AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural. AEBSF also inhibits activation of TGF? (transforming growth factor beta), moderately inhibits CD26 (Dipeptidyl peptidase IV: DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations. This product maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF and DFP.



Quantity Price  
1gm $199.00
5gm $918.00
500mgm $122.00


Soluble in water (10 g/L) at 20 °C, and DMSO (50 mg/ml). AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural. AEBSF also inhibits activation of TGF? (transforming growth factor beta), moderately inhibits CD26 (Dipeptidyl peptidase IV: DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations. This product maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF and DFP.

1. Baker, B.R., et al. 1971. J. Med. Chem. 14: 119-125. PMID: 5544395 2. Markwardt, F., et al. 1974. Biochem. Pharmacol. 23: 2247-2256. PMID: 4859519 3. Lawson, W.B., et al. 1982. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 109: 52-60. PMID: 6177608 4. Ohkubo, I., et al. 1994. J. Biochem. 116: 1182-1186. PMID: 7896751 5. Citron, M., et al. 1996. Neuron. 17: 171-179. PMID: 8755488 6. Solovyan, V.T. and Keski-Oja, J. 2006. J. Cell. Physiol. 207: 445-453. PMID: 16447253 7. Seto, T., et al. 2009. Biochem. Biophys. Res. Commun. 379: 681-685. PMID: 19103172

  • AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor 
  • Inhibits the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural. AEBSF also inhibits activation of TGF beta (transforming growth factor beta), moderately inhibits CD26 (Dipeptidyl peptidase IV: DPP IV) and activates JNK and p38 MAP kinases 
  • AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations 
  • AEBSF maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF and DFP 
  • Soluble in water (10 g/L) at 20 °C, and DMSO (50 mg/ml) 
  • Reactive towards: amino groups