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MPBH

(Protein Crosslinker heterobifunctional)


CL216   4-(N-Maleimidophenyl)butyric acid hydrazide hydrochloride
  f.w.: 309.7 daltons

MPBH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).


Quantity Price  
50mgm $144.90
100mgm $273.70


Spacer arm 17.9 angstroms. Heterobifunctional crosslinker. Carbohydrate selective and sulfhydyl reactive. MPBH has an oxidized carbohydrate specific hydrazide, a sulfhydryl reactive group and a spacer arm to accommodate a wide range of molecular coupling manipulations.
1.Chamow, S.M., Kogan, T.P., Peers, D.H., Hastings, R.C., Byrn, R.A. and Askenaszi, A. (1992). Conjugation of soluble CD4 without loss of biological activity via a novel carbohydrate-directed crosslinking reagent. J. Biol. Chem. 267(22), 15916-15922.
• Has an oxidized carbohydrate specific hydrazide, a sulfhydryl reactive group and spacer arms to accommodate a wide range of molecular coupling demands
• -SH specific group is a maleimide that yields a thioether linkage upon coupling
• Stable in DMSO
• Reactive groups: hydrazide and maleimide
• Reactive towards: carbohydrate and sulfhydryl groups
• Use with EDC for reactivity toward carboxyl groups
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