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KMUH

(Protein Crosslinker heterobifunctional)


CL224   N-(kappa-Maleimidoundecanoic acid) hydrazide
  f.w.: 295.4 daltons

KMUH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).



Quantity Price  
50mgm + $103.50
100mgm + $195.50


Spacer arm 19.0 angstroms. Heterobifunctional crosslinker. Sulfhydryl reactive and carbonyl reactive. Long non-cleavable aliphatic spacer arm. Hydrazide group covalently couples to oxidized carbohydrate residues in glycoproteins and other glycoconjugates.

1. Trail, P.A., et al. (1993). Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 261, 212-215.

  • Sulfhydryl-reactive and carbonyl-reactive heterobifunctional crosslinking agent
  • Long, non-cleavable, aliphatic cross-bridge
  • Hydrazide group covalently couples to oxidized carbohydrate residues in glycoproteins and other glycoconjugates
  • Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
  • Reactive groups: maleimide and hydrazide
  • Reactive toward: sulfhydryl and carbonyl (aldehyde)/carboxyl groups