GC Diagnostic Reagents MBTFA
Acylation derivatization reagent
For trifluoroacylating primary and secondary amines, hydroxyl and
thiol groups under mild non-acidic conditions.
GC116 N-Methylbis(trifluoroacetamide), 99+%
[ 685-27-8 ] f.w.:223.1daltons
b.p. 120-122°; d. 1.547
-
Trifluoroacetylates primary and secondary amines, as well as hydroxyl and thiol groups under mild nonacidic conditions
- Principal byproduct from the derivatization reaction is N-methyltrifluoroacetamide,
which is stable, volatile and does not present problems in
subsequent GC
- Produces very volatile derivatives of carbohydrates and can
be used to selectively acylate amines in th presence of hydroxyl
and carboxyl groups that have been protected by silyation
Application
- N-Methyl-bis(trifluoroacetamide) (MBTFA) trifluoroacetylates primary and secondary amines, hydroxyl and thiol groups under mild non-acidic conditions. The principal by-product from the derivatization reaction is N-methyltrifluoroacetamide, which is stable, volatile and does not present problems in subsequent gas chromatography. Sullivan and Schewe (1) have reported using MBTFA to prepare volatile TFA derivatives of mono-, di- and tri-saccharides with good yield. Subsequent gas chromatography showed excellent separations with retention times substantially lower than the corresponding TMS derivatives, for all compounds tested.
References
- Sullivan, J. E., et al. (1977). Preparation and gas chromatography of highly volatile trifluoroacetylated carbohydrates using N-Methyl-bis(trifluoroacetamide). J. of Chromatography Science 15, 196.
| unit | price |
| 10gm | $75.00 |
| 25gm | $132.00 |
| 100gm | $333.00 |
The products are packaged in hypovials with septum inserts for ease in sampling and use. We manufacture these products so bulk quotations are always available with substantial savings.
Each product is accompanied with a certificate of analysis including the GC chromatogram from QC