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PMPI

(Protein Crosslinker heterobifunctional)


CL223   N-(p-Maleimidophenyl)isocyanate
  f.w.: 214.2 daltons

PMPI is a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups (cysteines) after conjugating the linker to hydroxyl groups on a molecule by urethane (carbamate) bonds



Quantity Price  
50mgm + $176.00
100mgm + $333.00
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Spacer arm 8.7 angstroms. Heterobifunctional crosslinker. Novel sulfhydryl and hydroxyl reactive crosslinker. Non-cleavable. Excellent tool for the preparation of conjugates of hydroxyl containing compounds such as steriods and vitamins.

  1. Annunziato, M.E., Patel, U.S., Ranade, M. and Palumbo, P.S. (1993). p-Maleimidophenyl isocyanate: A novel heterobifunctional linker for hydroxyl to thiol coupling. Bioconjugate Chem. 4, 212-218.
  • Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
  • Isocyanate reacts with OH groups to form a carbamate link at pH 8.5
  • Excellent tool for conjugating OH group-containing compounds such as steroids and vitamins
  • Novel sulfhydryl- and hydroxyl-reactive heterobifunctional crosslinker
  • Non-cleavable
  • Reactive groups: maleimide and isocynate
  • Reactive toward: sulfhydryl and hydroxyl groups