Home > Products > DTBA

DTBA

(Protein Modifier)


M120   Dibutylthioamine, 99+%
  f.w.: 137.23 daltons

DTBA is simply the best reducing agent for reducing disulfide bonds. Approximately 20% of human proteins are predicted to contain disulfide bonds between cysteine residues. DTBA has thiol pKa values that are approximately 1 unit lower than DTT and forms a disulfide with a similar E value. DTBA reduces disulfide bonds faster than DTT, especially in neutral aqueous systems. The amino group of DTBA enables its isolation by cation exchange and facilitates its conjucation. DTBA is simply the best reagent for reducing disulfide bonds in aqueous solutions. Dibutylthioamine has very desirable physicochemical attributes. The HCl salt of DTBA is nearly odorless with a high solubility in water.



Quantity Price  
1gm $49.00
2.5gm $110.00
5gm $207.00


syn. (2S)-2-Amino-1,4-dimercaptobutane

1. JACS 134, 4057-4059 (2012).

  • DTBA is simply the best reducing agent for reducing disulfide bonds
  • DTBA has thiol pKa values that are approximately 1 unit lower than DTT and forms a disulfide with a similar E value
  • DTBA reduces disulfide bonds faster than DTT, especially in neutral aqueous systems
  • The amino group of DTBA enables its isolation by cation exchange and facilitates its conjucation
  • DTBA is simply the best reagent for reducing disulfide bonds in aqueous solutions
  • Dibutylthioamine has very desirable physicochemical attributes
  • The HCl salt of DTBA is nearly odorless with a high solubility in water
  • Approximately 20% of human proteins are predicted to contain disulfide bonds between cysteine residues
  • Kinetics rather than thermodynamics controls the reduction