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DTBA

(Protein Modifier)


M120   Dithiobutylamine, 99+%
  f.w.: 137.23 daltons

Dithiobutylamine (DTBA) is simply the best reducing agent for reducing disulfide bonds. Approximately 20% of human proteins are predicted to contain disulfide bonds between cysteine residues. DTBA has thiol pKa values that are approximately 1 unit lower than DTT and forms a disulfide with a similar E value. Dithiobutylamine reduces disulfide bonds faster than DTT, especially in neutral aqueous systems. The amino group of DTBA enables its isolation by cation exchange and facilitates its conjucation. DTBA is simply the best reagent for reducing disulfide bonds in aqueous solutions. Dithiobutylamine has very desirable physicochemical attributes. The HCl salt of DTBA is nearly odorless with a high solubility in water.



Quantity Price  
1gm $49.00
2.5gm $110.00
5gm $207.00


syn. (2S)-2-Amino-1,4-dimercaptobutane

1. JACS 134, 4057-4059 (2012).

  • Dithiobutylamine (DTBA) is simply the best reducing agent for reducing disulfide bonds
  • DTBA has thiol pKa values that are approximately 1 unit lower than DTT and forms a disulfide with a similar E value
  • Dithiobutylamine reduces disulfide bonds faster than DTT, especially in neutral aqueous systems
  • The amino group of DTBA enables its isolation by cation exchange and facilitates its conjucation
  • DTBA is simply the best reagent for reducing disulfide bonds in aqueous solutions
  • Dithiobutylamine has very desirable physicochemical attributes
  • The HCl salt of DTBA is nearly odorless with a high solubility in water
  • Approximately 20% of human proteins are predicted to contain disulfide bonds between cysteine residues
  • Kinetics rather than thermodynamics controls the reduction